Asian Journal of Research and Reports in Neurology

The uncontrolled, repetitive use of Cannabis sativa continues to pose a problem for the plant's potential medical benefits. Because cannabis is a psychoactive chemical with a variety of physiological qualities, the start and intensity of its effects are frequently influenced by the way it is consumed. This present study is aimed at investigating the effects of daily oral ingestion of C. sativa on memory and its amnestic tendencies in wistar rats. Twenty-five albino wistar rats were acclimated to laboratory condition for fourteen days, following which they were separated into 5 groups of 5 animals each. Group I were used as control receiving only distilled water orally, Group II-IV were administered with 0.1ml, 0.2ml and 0.3ml cannabis via oral route respectively for 21days, while group V animals were administered with epinephrine. Cognitive activities were assessed using passive avoidance test, barnes maze test and navigation maze test. The brain oxidative stress markers that were used to determine stress activities include Superoxide dismutase, catalase, reduced glutathione and malondialdehyde’. Results gotten were analyzed and some activities were statically significant (p< 0.05) in comparison to the control group. For instance, Cannabis significantly decreased the activity of Superoxide dismutase, reduced glutathione and malondialdehyde but caused an increase in catalase activity when compared to the control. It was also observed that the animals that were administered with cannabis displayed significantly reduced amnesia as the study progressed, increased better stress management and positive enhancement in memory compared to the control. In conclusion, it can be deduced from the result that cannabis demonstrated significantly, (p<0.05) cellular re-alignment and rejuvenation in terms of oxidative stress markers activities and potent memory retrieval as the period of administration progressed.