Asian Journal of Research and Reports in Neurology <p style="text-align: justify;"><strong>Asian Journal of Research and Reports in Neurology</strong>&nbsp;aims&nbsp;to publish&nbsp;high-quality&nbsp;papers (<a href="/index.php/AJORRIN/general-guideline-for-authors">Click here for Types of paper</a>) in all aspects of&nbsp;‘Neurology’. This journal facilitates the research and wishes to publish papers as long as they are technically correct, scientifically motivated. The journal also encourages the submission of useful reports of negative results. This is a quality controlled,&nbsp;OPEN&nbsp;peer-reviewed, open access INTERNATIONAL journal.</p> en-US (Asian Journal of Research and Reports in Neurology) (Asian Journal of Research and Reports in Neurology) Mon, 01 Feb 2021 10:32:30 +0000 OJS 60 Cerebral Venous Thrombosis: Study of 12 Cases from Southern Brazil <p>Cerebral venous thrombosis (CVT) is a pathology that affects the cerebral venous sinuses causing an ischemic and/or hemorrhagic brain, but, contrary to the arterial cerebral vascular accident, has a clinical presentation with varied signs and symptoms that are difficult to diagnose in the its initial phase. Objective: To present the clinical findings of twelve cases of CVT. Materials and methods: We reviewed the charts of patients admitted with a diagnosis of CVT. Results: We describe 8 females and 4 males, with mean age of 30 years. The most common signs and symptoms were: headache (89%), seizure (55.5%), cranial nerve palsy (44%) and hemiparesis (33%). All patients had diagnoses confirmed by nuclear magnetic resonance of the skull. The risk factors found were the use of oral and puerperium contraceptives. All patients were treated with oral anticoagulant, with no death reported in this series. Conclusion: Venous sinus thrombosis is an uncommon disease that requires a high index of suspected diagnosis by the medical team. The mortality rate is low and the treatment is usually effective.</p> Otto Jesus Hernandez Fustes, Carlos Arteaga Rodriguez, Georgette Mouchaileh E. Ferreira ##submission.copyrightStatement## Wed, 17 Feb 2021 00:00:00 +0000 Novel Insights into Neuroprotective Strategies Employing NQO1 and DCLK1 in Parkinson’s Disease <p>Parkinson’s disease (PD) is the most common movement disorder and is only second to Alzheimer’s disease in most prevalent neurodegenerative diseases. Diverse causative factors lead to PD pathology among which oxidative stress and accumulation of α-Synuclein aggregates are considered to be key determinants for both sporadic and familial forms. In this review we focus on two novel research efforts to block elevated oxidative stress and α-Syn aggregates to provide neuroprotection to the dopaminergic neurons and thereby alleviating the motor symptoms displayed in PD animal models. A recently published effort from Luo and colleagues, discovered a pathway where the neuroprotective protein NQO1 is degraded upon phosphorylation by activated Akt and making the dopaminergic neurons susceptible to demise via elevated oxidative stress. Another recent report by Vázquez-Vélez and colleagues explored the regulatory relationship between the neuron expressed kinase DCLK1 and α-Syn in the context of human cellular and mouse models. These discoveries concentrate on different mechanisms of preventing the dopaminergic neurodegeneration in PD by reducing the oxidative stress and α-Syn aggregation via regulating key determinants of PD pathophysiology, NQO1 and DCLK1 respectively. This review emphasizes the possibility of employing both NQO1 and DCLK1 as promising therapeutic targets leading to future prospects of combinational therapies for devastating diseases like PD.</p> Kandage, M. Shyami, Silva, N. Gayathri, Gamage, K. Kanchana ##submission.copyrightStatement## Tue, 02 Mar 2021 00:00:00 +0000 The Pathophysiology of Traumatic Brain Injury (TBI): A Review <p>Traumatic brain injury (TBI) is an insult to the brain from an external mechanical force. It may cause permanent or temporary impairment of cognitive, physical, and/or psychological functions. It may also be associated with an altered or diminished state of consciousness. It accounts for approximately 40% of all deaths from acute injuries. The economic burden due to loss of earning capacity is tremendous. It affects all age groups, but the main victims are the adults in the prime of their life. The major cause of TBI is road traffic accidents. The primary injury, sustained at the time of the accident, cannot be altered. The main aim of TBI management is to prevent or limit the secondary brain injury which develops after Primary injury. The proper recognition of trauma and secondary pathology goes a long way to limit mortality and morbidity. The skull fractures, intracranial bleeds can be surgically treated. Early recognition of cerebral edema, raised intracranial tension, hydrocephalus and brain herniation is the essential part of neurosurgical management.</p> Sujan Narayan Agrawal ##submission.copyrightStatement## Mon, 01 Feb 2021 00:00:00 +0000