Anti-Neuroinflammatory Potential of Herbal Formulations in Attenuation of Neurodegenerative Diseases

M. Ganga Raju *

Department of Pharmacology, Gokaraj Rangaraju College of Pharmacy, Nizampet-Bachupally Road, Bachupally, Hyderabad, Telanangana 500090, India.

K. Keerthana

Department of Pharmacology, Gokaraj Rangaraju College of Pharmacy, Nizampet-Bachupally Road, Bachupally, Hyderabad, Telanangana 500090, India.

N. V. L. Suvarchala Reddy V.

Department of Pharmacology, Gokaraj Rangaraju College of Pharmacy, Nizampet-Bachupally Road, Bachupally, Hyderabad, Telanangana 500090, India.

K. V. Srinija

Department of Pharmacology, Gokaraj Rangaraju College of Pharmacy, Nizampet-Bachupally Road, Bachupally, Hyderabad, Telanangana 500090, India.

P. Sravya

Department of Pharmacology, Gokaraj Rangaraju College of Pharmacy, Nizampet-Bachupally Road, Bachupally, Hyderabad, Telanangana 500090, India.

*Author to whom correspondence should be addressed.


The reaction characterized by inflammation in the brain or the spinal column is known medically as "neuroinflammation." The central nervous system is impacted by neurodegeneration, which is epitomized by the loss of neural functioning and structure. Neurodegeneration occurs as a result of viral infection. It is mostly observed in a range of conditions referred to as "neurodegenerative diseases," which primarily affect the elderly and hurt mental as well as physical performance. These illnesses include amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Neurodegeneration's fundamental causes continue to remain a mystery. Nevertheless, new research indicates that several neurodegenerative mechanisms that are related to depression a side effect of neurodegenerative disease are intimately associated with the inflammatory process. Cytokines that promote inflammatory processes are crucial to understanding the pathophysiology of depression and dementia. Activated microglial cells are believed to play a major role in the inflammatory and immune responses that occur in neurological conditions and neurodegenerative conditions. Signaling chemicals are produced throughout neuroinflammation and these molecules regulate multiple pro-apoptotic mechanisms. Treatment strategies for neurological conditions with an inflammatory component involve grasping neurological inflammation pathways, controlling the generation of cytokines, and managing the microglial inflammatory reaction. Some herbal formulations discussed in this review like curcumin and rutin were useful in the therapy of neuroinflammation induced neurodegeneration.

Keywords: Neuroinflammation, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease

How to Cite

Raju , M. G., Keerthana , K., N. V. L. Suvarchala Reddy V., Srinija , K. V., & Sravya , P. (2023). Anti-Neuroinflammatory Potential of Herbal Formulations in Attenuation of Neurodegenerative Diseases. Asian Journal of Research and Reports in Neurology, 6(1), 185–193. Retrieved from


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Carson MJ, Doose JM, Melchior B, Schmid CD, Ploix CC. CNS immune privilege: hiding in plain sight. Immunological reviews. 2006;213(1):48-65. Available:

Lyman M, Lloyd DG, Ji X, Vizcaychipi MP, Ma D. Neuroinflammation: the role and consequences. Neuroscience research. 2014;79: 1-2.


Park SE, Sapkota K, Kim S, Kim H, Kim SJ. Kaempferol acts through mitogen‐activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells. British journal of pharmacology. 2011;164(3):1008-25. Available:

Giatti S, Boraso M, Melcangi RC, Viviani B. Neuroactive steroids, their metabolites, and neuroinflammation. Journal of molecular endocrinology. 2012;49(3): R125-34.

Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH. Mechanisms underlying inflammation in neurodegeneration. 2010; 140(6):918-34.

Harry GJ, Kraft AD. Neuroinflammation and microglia: considerations and approaches for neurotoxicity assessment. Expert opinion on drug metabolism & toxicology. 2008;4(10):1265-77.

Li T, Lu L, Pember E, Li X, Zhang B, Zhu Z. New Insights into Neuroinflammation Involved in Pathogenic Mechanism of Alzheimer's disease and Its Potential for Therapeutic Intervention. Cells. 2022;11 (12):1925.

Allan SM, Rothwell NJ. Inflammation in central nervous system injury. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 2003;358(1438):1669-77.


Nitsch R, Bechmann I, Deisz RA, Haas D, Lehmann TN, Wendling U, Zipp F. Human brain-cell death induced by tumour-necrosis-factor-related apoptosis-inducing ligand (TRAIL). The Lancet. 2000;356 (9232):827-8.


Blamire AM, Anthony DC, Rajagopalan B, Sibson NR, Perry VH, Styles P. Interleukin-1β-induced changes in blood–brain barrier permeability, apparent diffusion coefficient, and cerebral blood volume in the rat brain: a magnetic resonance study. Journal of Neuroscience. 2000;20(21):8153-9.

Swaroop S, Sengupta N, Suryawanshi AR, Adlakha YK, Basu A. HSP60 plays a regulatory role in IL-1β-induced microglial inflammation via TLR4-p38 MAPK axis. Journal of neuroinflammation. 2016;13:1- 9.

Noh H, Jeon J, Seo H. Systemic injection of LPS induces region-specific neuro-inflammation and mitochondrial dysfunction in normal mouse brain. Neurochemistry International. 2014;69:35-40. Available: 2014.02.008

Naik E, Dixit VM. Mitochondrial reactive oxygen species drive proinflammatory cytokine production. Journal of Experimental Medicine. 2011;208(3):417-20.


Roy S, Packer L. Redox regulation of cell functions byalpha‐lipoate: biochemical and molecular aspects. Biofactors. 1998;7 (3):263-7.


Mohammed Akbar, Musthafa Mohamed Essa, Ghazi Daradkeh, Mohamed A. Abdelme geed, Youngshim Choi, Lubna Mahmood, Byoung-Joon Song. Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain Research. 2016; 1637:34–55.

Available: rainres.2016.02.016

Peng YL, Liu YN, Liu L, Wang X, Jiang CL, Wang YX. Inducible nitric oxide synthase is involved in the modulation of depressive behaviors induced by unpredictable chronic mild stress. Journal of Neuroinflammation. 2012;9:1-2.

Terazawa R, Akimoto N, Kato T, Itoh T, Fujita Y, Hamada N, Deguchi T, Iinuma M, Noda M, Nozawa Y, Ito M. A kavalactone derivative inhibits lipopolysaccharide-stimulated iNOS induction and NO production through activation of Nrf2 signaling in BV2 microglial cells. Pharmacological Research. 2013;71:34-43.


Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiological reviews. 2001;81(2):807-69. Available:

Cowan KJ, Storey KB. Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress. Journal of Experimental Biology. 2003;206(7):1107-15.

Crutcher KA, Gendelman HE, Kipnis J, Perez-Polo JR, Perry VH, Popovich PG, Weaver LC. Debate:“is increasing neuroinflammation beneficial for neural repair?”. Journal of Neuroimmune Pharmacology. 2006;195-211.

Ostanin DV, Bao J, Koboziev I, Gray L, Robinson-Jackson SA, Kosloski-Davidson M, Price VH, Grisham MB. T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2009;296(2):G135-46.

Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000prime reports. 2014;6.

González H, Elgueta D, Montoya A, Pacheco R. Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseases. Journal of neuroimmunology. 2014;274(1-2):1-3.

Henkel JS, Engelhardt JI, Siklós L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH. Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Annals of Neurology: Official Journal of the American Neurological Association and the Child Neurology Society. 2004;55(2):221-35.

Rock RB, Gekker G, Hu S, Sheng WS, Cheeran M, Lokensgard JR, Peterson PK. Role of microglia in central nervous system infections. Clinical microbiology reviews. 2004;17(4):942-64.

Querfurth HW, LaFerla FM. Alzheimer's disease. New England Journal of Medicine. 2010;362(4):329-44.

Pawar YB, Munjal B, Arora S, Karwa M, Kohli G, Paliwal JK, Bansal AK. Bioavailability of a lipidic formulation of curcumin in healthy human volunteers. Pharmaceutics. 2012;4(4):517-30.

Parada E, Buendia I, Navarro E, Avendaño C, Egea J, López MG. Microglial HO‐1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects. Molecular nutrition & food research. 2015;59(9):1690-700.

Priprem A, Watanatorn J, Sutthiparinyanont S, Phachonpai W, Muchimapura S. Anxiety and cognitive effects of quercetin liposomes in rats. Nanomedicine: nanotechnology, biology and medicine. 2008;4(1):70-8.

Available: 2007.12.001

Gaillard PJ, Appeldoorn CC, Rip J, Dorland R, van der Pol SM, Kooij G, de Vries HE, Reijerkerk A. Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation. Journal of Controlled Release. 2012;164(3):364-9.


Zhang W, Xiao D, Mao Q, Xia H. Role of neuroinflammation in neurodegeneration development. Sig Transduct Target Ther. 2023;8:267.

Yadav S, Gandham SK, Panicucci R, Amiji MM. Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammation. Nanomedicine: Nanotechnology, Biology and Medicine. 2016;12(4):987-1002.


Javed H, Khan MM, Ahmad A, Vaibhav K, Ahmad ME, Khan A, Ashafaq M, Islam F, Siddiqui MS, Safhi MM. Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type. Neuroscience. 2012;210: 340-52.