Asian Journal of Research and Reports in Neurology

Holoprosencephaly: Apropos of 2 Cases

A. Fadil *

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

N. Hazzab

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

W. Lahmini

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

M. Bourrous

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

*Author to whom correspondence should be addressed.

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Abstract

A rare brain malformation known as holoprosencephaly is caused by the forebrain's (prosencephalon) incomplete division during the third to fourth week of pregnancy. It frequently occurs in conjunction with expressive facial anomalies, most notably cleft lip and palate. Through two cases of alobar and semi lobar holoproencephaly, we try to focus on this malformation, thus defining the Three forms. These Three anatomical forms are distinguished according to the degree of individualization of the cerebral hemispheres: the alobar, semi-lobar and lobar form. The prognosis is reserved. Prenatal diagnosis can be made by fetal ultrasound.

Keywords: Brain malformation, holoprosencephaly, prenatal diagnosis, neurological manifestations

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