Holoprosencephaly: Apropos of 2 Cases

A. Fadil *

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

N. Hazzab

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

W. Lahmini

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

M. Bourrous

Pediatric Emergency Department, CHU Mohammed VI, Marrakech, Morocco.

*Author to whom correspondence should be addressed.


A rare brain malformation known as holoprosencephaly is caused by the forebrain's (prosencephalon) incomplete division during the third to fourth week of pregnancy. It frequently occurs in conjunction with expressive facial anomalies, most notably cleft lip and palate. Through two cases of alobar and semi lobar holoproencephaly, we try to focus on this malformation, thus defining the Three forms. These Three anatomical forms are distinguished according to the degree of individualization of the cerebral hemispheres: the alobar, semi-lobar and lobar form. The prognosis is reserved. Prenatal diagnosis can be made by fetal ultrasound.

Keywords: Brain malformation, holoprosencephaly, prenatal diagnosis, neurological manifestations

How to Cite

Fadil , A., Hazzab, N., Lahmini , W., & Bourrous , M. (2023). Holoprosencephaly: Apropos of 2 Cases. Asian Journal of Research and Reports in Neurology, 6(1), 27–30. Retrieved from https://journalajorrin.com/index.php/AJORRIN/article/view/73


Download data is not yet available.


Chellaoui M, Chat L, Najid A, Ben Amour-Ammar H. Alobar holoprosencephali: about a case. Medicine of the Maghreb. 1999;75.

Dia Aliou Amadou, D'Almeida Franck, Mbodji Mamadou, Ka Mamadou Mourtalla; Alobar holoprosencephaly in a context of polymalformative syndrome: contribution of imaging, about a case. Pan African Medical Journal; 2013.

Forci K, Alami MH, El Barnoussi L, Chkirate M, Bezad1 R, Smiress N, Mdaghri Alaoui A, Thimou Izgua A. Holoprosencephaly: About a case; Moroccan Journal of Medical Sciences 2014;XIX:#4.

Anastasia Zikou, Vasileios Xydis, Meropi Tzoufi; Case 12630 Semilobar holoprosencephaly with a median cleft: case report; Eurorad 2015;12.

Bendavid C, Dupé V, Rochard L, Gicquel I, Dubourg C, David V. Holoprosencephaly: An update on cytogenetic abnormalities. Am J Med Genet C Semin Med Genet. 2010;154C(1):86–92.

Siala Gaigi S, Masmoudi A, Chennoufi MB, Jabnoun et al, Diagnosis of holoprosencephaly. Apropos of 17 cases [Diagnosis of holoprosencephalia. Report of 17 cases]. Tunis Med. 2001;79(10): 526-9.

Albu CC, Albu DF, Patrascu A, Albu SD, Efrem IC, Goganau AM. Prenatal diagnosis of syndromic alobar holoprosencephaly associated with digynic triploidy fetus. Rom J Morphol Embryol. 2020;61(4):1309–1316.