Epidemiology, Clinical Presentation and Outcome of Neonatal Convulsion at Tobruck Medical Center - Libya

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Mohanad Abdulhadi Saleh Lawgali
Faiaz Ragab Salem Halies
Amina M. Beayou
Nasren Gamal Saleh Al-Fraik
Khadeejah Miftah Ali Al-Khurum


Neonatal seizures are the most prominent feature of neurological dysfunction during neonatal period. Seizures in the neonatal population often present differently than in other age groups due to brain immaturity. However, in neonates there may be no clinical movement abnormality either because the seizures are subclinical or because they cannot be noticed. This study aimed to determine the natural history, the time of onset, the etiological factors, the clinical types, the treatment, and the short-term outcomes of neonatal convulsion. This cross sectional descriptive study was conducted in The Neonatal Intensive Care Unit at Tobruck Medical Centre from the 1st of January 2017 to the end of January 2018. During this, 642 neonates were admitted to NICU, out of which 27 had seizures. 17 (62.7%) of the babies were males and 10 (37%) were females. All of them were Libyans; 70.3% were from Tobruck city.

Neonatal seizure, neonatal intensive care unit, risk factors, complications, outcome, Libya.

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How to Cite
Lawgali, M. A. S., Halies, F. R. S., Beayou, A. M., Al-Fraik, N. G. S., & Al-Khurum, K. M. A. (2021). Epidemiology, Clinical Presentation and Outcome of Neonatal Convulsion at Tobruck Medical Center - Libya. Asian Journal of Research and Reports in Neurology, 4(1), 38-46. Retrieved from http://journalajorrin.com/index.php/AJORRIN/article/view/30120
Short Research Article


Singh M. Neurological disorders. In: Textbook of care of newborn. Delhi Sagar Publication. 2010;340-344.

Mikati MA, Kliegman RM, et al. Seizures in childhood. Philadelphia: WB Saunders. 2011;586:2013-2037.

Younkin DP, Delivoria-Papdopoulos M, et al. Cerebral metabolic effects of neonatal seizures measured with in vivo pNMR spectroscopy. Ann Neurol. 1986;20:513-519.

Volpe JJ. Neonatal Seizures. In Neurology of the newborn. Philadelphia: WB Saunders. Neonatal Seizures. 2008;172-225.

ILAE. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League against Epilepsy. Epilepsia. 2009;30(4): 389-399.

Rennie JM, Bylan GB. Neonatal seizures. In: David TJ, Ed. Recent Advances in Paediatrics 18. Edinburgh: Churchill Livingstone. 2002;19–32.

Al Yasiri, A Adeebah. the etiology of seizures among neonates admitted to Babylon Gynecology and Pediatrics teaching hospital; Dept. Pediatrics, Babylon Medical College, Babylon University, Hilla-Iraq- Babylon Maternity and Children Teaching Hospital. 2015;2 (1):30-40.

Mosley M. Neonatal Seizure Pediatric in Review. 2010;31:127-8.

Mary Jo Lanska, Douglas J. Lanska et al. A population-based study of neonatal seizures in Fayette County, Kentucky. Neurology. 2000;45(4)724- 732.

Anand V, Nair PM. Neonatal seizures: Predictors of adverse outcome; Department of Pediatrics, SreeGokulam Medical College and Research Foundation, Thiruvananthapuram, Kerala, India. J Pediatr Neurosci. 2014;9(2):97-9.
DOI: 10.4103/1817-1745.139261

Alcover-Bloch E, Campistol J, et al. Neonatal seizures, our experience. Rev Neurol. 2004;38:808-812.

Sabzehei M, Basiri B, et al. The etiology, clinical type, and short outcome of seizures in Newborns Hospitalized in Besat Hospital/Hamadan/ Iran, Iran J Child Neural, spring. 2014;8(2): 24-28.

Yaser S Abd. A clinical study of neonatal convulsion in al Khansaah teaching hospital for pediatrics in Mosul, thesis for Fellowship Degree of FIBMS Pediatric. 2004;23.

Al Marzoki, M Jasim. Clinco-Biochemical Profile of Neonatal Seizures at Dept. Pediatrics, Babylon Medical College, Babylon University, Hilla-Iraq- Babylon Maternity and Children Teaching Hospital, Des QMJ. 2010;6:10: 163-168.

Najeeb S, Qureshi AM, et al. Aetiology and types of neonatal seizures presenting at Ayub Teaching Hospital Abbottabad. J Ayub Med Coll Abbottabad. 2012;24(1):33-37.

Malik BA, Butt MA, et al. Seizures etiology in the newborn period. J Coll Physicians Surg Pak. 2005;15:786-790.

Kumar Ashok, Veenu Gupta, et al. Biochemical abnormalities in neonatal seizures; The department of pediatrics, Institute of Medical Sciences, and the Department of Metallurgy, Institute of Technology, Banaras Hindu University, Varanasi. India. 2004;32.

Sambhaji S Wagh, Krupa J, Rambhia A. study of clinical profile of neonatal seizures. International Journal of Recent Trends in Science and Technology. October. 2013;20(3):343-348.

Lopes A, Vilan A, et al. Neonatal seizures in a tertiary neonatal intensive care unit. Acta Med Port. 2003;25(6):368-74.

Alcover-Bloch E, Campistol J, et al. Neonatal seizures, our experience; Hospital Sant Joan de Déu, Esplugues de Ll, Barcelona, Spain. Rev Neurol. 2003;(9):80-81.

Doménech-Martínez E, Castro-Conde JR, et al. Neonatal convulsions: Influence of the electroencephalographic pattern and the response to treatment on the outcome; Servicio de Neonatología, Hospital Universitario de Canarias, La Laguna, spain. Revista de Neurologia, 2001;37(5):413-420.

Gabriel M. Ronen, Sharon Penney et al. The epidemiology of clinical neonatal seizures in Newfoundland: A population-based study; Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. J Pediatr. 2008;134(1): 71-5.

Mahmood Arshad, Syed Qamar Zaman, et al. Neonatal seizures; types, etiology at a tertiary care hospital; PNS Shifa Naval Hospital, Karachi. Pakistan. Profes¬sional Med J. 2014;21(5):1048-1053.

Bushra AM, Butt MA, et al. Seizures etiology in the newborn period”, J Coll Physicians Surg Pak. 2005;15(12): 786-90.

Wong Michael. Neonatal Seizures; University School of Medicine and an epileptologist in the Pediatric Epilepsy Center at St. Louis Children’s Hospital. Washington. USA; 2006.

Sahana G, Anjaiah B. Clinical profile of neonatal seizures, Int J Med Applied Sci. 2014;3:21-7.

Lawgali MAS, Halies FRS, Beayou AM. Etiology and short term outcome of neonatal convulsion in NICU at Benghazi Children Hospital. Neuroscience and Medicine. 2019;10:369-384.