Landau–Kleffner Syndrome (Acquired Epileptic Aphasia) about a 13 Year Old Child: A Case Report

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Ouajid El. Bakkali
Sanae El. Moussaoui
Yamna Kriouile


Landau-Kleffner syndrome or acquired epileptic aphasia is an acquired infantile epileptic syndrome. It was identified by Landau and Kleffner in 1957, where six affected children were listed. It is characterized by an acute loss of speech and language and an overall regression of behavior in a child who had good psychomotor development with language normal. The rarity of this syndrome makes it demanding to diagnose. Multidisciplinary treatment will be required by pediatricians, neuropediatricians, child psychiatrists, psychologists, speech-language pathologists, otolaryngologists and radiologists. The final diagnosis is based on an altered EEG during sleep with a normal brain MRI, as well as clinical manifestations syndrome. we report the case of a 13-year-old child, with good psychomotor and cognitive development, from 1st degree inbred parents, there was no family history of childhood epileptic disorder, having presented six months ago 15 minute tonic-clonic straight hemicrises and a dysgraphia was installed gradually, against a background of apyrexia. These symptoms progressed six months later, towards a very significant regression of the oral language with difficulties of articulation and a total regression written. The sensory and motor examination was normal. The cranial nerves were intact. The walk was normal. The systemic examination was without abnormality. The studies on cerebrospinal fluid (CSF) were normal. Magnetic resonance imaging (MRI) of the brain with contrast is normal. EEG objectified short, predominantly centro-temporal biphasic short bursts and during sleep, the presences of a central theta focus. The patient was put on sodium valproate, Levetiracetam, Clobazam, intravenous immunoglobulin and corticosteroid and speech therapy.

Landau-kleffner syndrome, acquired epileptic, aphasia.

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Bakkali, O. E., Moussaoui, S. E., & Kriouile, Y. (2020). Landau–Kleffner Syndrome (Acquired Epileptic Aphasia) about a 13 Year Old Child: A Case Report. Asian Journal of Research and Reports in Neurology, 2(2), 1-4. Retrieved from
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Deonna TW. Acquired epileptiform aphasia in children (Landau-Kleffner syndrome). J Clin Neurophysiol. 1991;8:288-298.

Pearl PL, Carrazana EJ, Holmes GL. The landau-kleffner syndrome. Epilepsy Curr. 2001;1:39- 45.

Ramanathan RS, Ahluwalia T, Sharma A. Landau-Kleffner syndrome-a rare experience. East J Med. 2012;17:36-39.

Nemati R, Nabipour I, Javadi H, Chabi N, Assadi M. Regional cerebral blood-flow with 99mTc- ECD brain perfusion SPECT in Landau-Kleffner syndrome: Report of two cases. Case Rep Radiol. 2014;1-5.

Raybarman C. Landau-Kleffner syndrome: A case report. Neurol India. 2002;50: 212-3.

Bishop DV. Age of onset and outcome in ‘acquired aphasia with convulsive disorder’ (Landau-Kleffner syndrome). Dev Med Child Neurol. 1985;27:705-12.

Landau WM, Kleffner FR. Syndrome of acquired aphasia with convulsive disorder in children. Neurology. 1957;7:523-30.

Gascon G, Victor D, Lombroso CT. Language disorders, convulsive disorder and electroencephalographic abnormalities. Acquired syndrome in children. Arch Neurol. 1973;28:156-625.

Tuchman RF. Acquired epileptiform aphasia. Semin Pediatr Neurol. 1997;4:93-101.

Maquet P, Hirsch E, Dive D, Salmon E, Marescaux C, Franck G, et al. Cerebral glucose utilization during sleep in Landau-Kleffner syndrome: A PET study. Epilepsia 1990;31:778-83.

Duran MH, Guimarães CA, Medeiros LL, Guerreiro MM. Landau-Kleffner syndrome: Long-term follow-up. Brain Dev. 2009;31: 58-63.

Beumonoir A. The Landau Kleffner syndrome. In: Roger J, Beureau M, Drovet CH, Dreifuss FE, Perret A, Wolf P, editors. Epileptic syndrome in infancy, childhood and adolescence. 2nd ed. London, England: John Libbey Eurotext. 1992;231-43.

Arts WF, Aarsen FK, Scheltens-de Boer M, Catsman-Berrevoets CE. Landau-Kleffner syndrome and CSWS syndrome: Treatment with Intravenous Immunoglobulins. Epilepsia. 2009;50 (Suppl 7):55-8.

Morrell F, Whisler WW, Smith MC, Hoeppner TJ, de Toledo-Morrell L, Pierre-Louis SJ, et al. Landau-Kleffner syndrome. Treatment with Subpial Intracortical Transection. Brain. 1995;118(Pt 6):1529-46.