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The presented clinical case describes a rare occurrence of progressive palsy with a tiger-eye effect on MRI. The issues of the workup and differential diagnosis were discussed. There was an argument that along with other MRI criteria for the diagnosis of Progressive Supranuclear Palsy (PSP), the above-described symptom of the "tiger eye" may occur in some patients with this disease. This radiological sign serves as a pathological correlative, indicating the possibility of developing neurodegenerative disease according to a single universal mechanism of neuronal death in various parts of the brain that determine the specificity of clinical manifestations.